星港家居以中台打造为基础核心,源于通过对SAAS系统的不断升级优化,与客户建立更紧密的关联,帮助客户进行科学化进销存管理,将政策扶持精细到位。
长期从事新型光功能材料的基础和应用探索研究,小题在低维材料、纳米光电子学等方面做出了开创性贡献。其中,源于PES-SO3H层充当功能层,PES-OHIm层充当支撑层。
小题2014年以成果低维光功能材料的控制合成与物化性能获国家自然科学奖二等奖(第一获奖人)。此外,源于研究人员展示了在金属箔上分层石墨烯合成的批量生产方法,证明了其技术可扩展性。曾获北京市科学技术奖一等奖,小题中国化学会青年化学奖,中国青年科技奖等奖励。
由于聚(芳基醚砜)的高分子量,源于该膜表现出良好的物理性能。现任北京石墨烯研究院院长、小题北京大学纳米科学与技术研究中心主任。
近期代表性成果:源于1、源于Angew:量身定制聚醚砜双极膜用于高功率密度的渗透能发生器中科院理化技术研究所江雷院士,闻利平研究员和Xiang-YuKong从相同的PES前体合成了带负电荷的磺化聚醚砜(PES-SO3H)和带正电荷的咪唑型聚醚砜(PES-OHIM),并采用无溶剂诱导相分离(NIPS)和旋涂(SC)法制备了一系列双极膜。
这些材料具有出色的集光和EnT特性,小题这是通过掺杂低能红色发射铂的受体实现的。3D打印机所提供的控制水平已使得在生产与生理相关的仿生组织和器官替代品方面取得许多显著进展,源于如药物测试,源于阐明生物机制,疾病模型,翻译医学和外科植入物等。
小题作者简介ShaochenChen,PhDProfessorandChairofNanoEngineering DepartmentUniversityofCalifornia,SanDiegoResearch: Dr.Chenisapioneerin3Dprintingandbioprintingwithover200peer-reviewedpublications.Hefirstinitiatedascanningless3Dprintingtechniquetermedmicro-stereolithography(µSL)forprojectionprintingofbiomaterialsin2006. BuildinguponhisµSLtechnique,heinventedadynamicopticalstereolithographymethod(DOPsL)in2012(AdvancedMaterials,2012).Comparedtotraditionalnozzle-based3Dprinting,DOPsLenables3Dprintingthatis3,000timesfasterinprintingspeedand100timesfinerinprintingresolution(NatureCommunications,2014).Hehascontinuedtoadvancethisfieldbydevelopingamicroscalecontinuousopticalbioprinting(µCOB)methodfortherapid3Dbioprintingoffunctionaltissuesmodelsinmereseconds.Usinghumaninducedpluripotentstemcells,hesuccessfullybioprintedfunctionallivertissuesthatenablediseasemodelinganddrugscreening(PNAS,2016).Furthermore,byintegratingneuronstemcellswithina3Dprintedbiomimeticscaffold,histeamhassucceededintherepairofaseverelydamagedspinalcordinratstoresultinsignificantfunctionalrecovery(NatureMedicine,2019).Hisground-breakingworkhasbeenreportedbyTheWashingtonPost,TheWallStreetJournal,Forbes,andYahooNews.Hispioneeringworkinmicroandnanoscale3Dprintingandbioprintingestablishedthefoundationfortheemergingfieldofbiofabricationfortissueengineeringandregenerativemedicineapplications.Hefoundedastartupcompany,Allegro3Dtocommercializehisbioprintingtechniques.Itisprovidingtransformativesolutionstoorgan/tissuerepairandregeneration,acceleratingdrugtoxicityandefficacytesting,andadvancinghumandiseasesmodeling.Dr.Chenhasreceivednumerousawards,includingtheNSFCAREERaward, ONRYoungInvestigatoraward,andNIHEdwardNagyNewInvestigatorAward.In2017,hereceivedtheMiltonC.ShawManufacturingResearchMedalfromASMEforhisseminalworkin3Dprinting,bioprinting,andnanomanufacturing.ThisisthehighestawardgivenbyASMEtorecognizeoriginalmanufacturingresearchinthefield.Dr.ChenisaFellowofmajorsocieties,includingtheAmericanAssociationfortheAdvancementofScience(AAAS),AmericanInstituteforMedicalandBiologicalEngineering (AIMBE),AmericanSocietyofMechanicalEngineers(ASME),InternationalSocietyforOpticsandPhotonics (SPIE),andInternationalSocietyforNanomanufacturing(ISNM).RepresentativePublications (outof203peer-reviewedpapers)LuandS.C.Chen*,MicroandNano-fabricationofBiodegradablePolymersforDrugDelivery,AdvancedDrugDeliveryReviews,Vol.56,pp.1621-1633,2004.Lu,G.Mapili,G.Suhali,S.C.Chen*,K.Roy*,ADigitalMicro-mirrorDevice-basedSystemfortheMicrofabricationofComplex,SpatiallyPatternedTissueEngineeringScaffolds,JournalofBiomedicalMaterialsResearchA,Vol.77A(2),pp396-405,2006.P. Zhang,X.Qu, P.Soman, K.C.Hribar, J.W.Lee, S.C.Chen*,andS.He,RapidFabricationofComplex3DExtracellularMicroenvironments byDynamicOpticalProjectionStereolithography,AdvancedMaterials,Vol.24(no.31),pp.4266-4270,2012.Zhu,J.Li,Y.Leong, I.Rozen,X.Qu,R.Dong,Z.Wu,W.Gao,P.H.Chung,J.Wang*, andS.C.Chen*,3DPrintedArtificialMicro-Fish,AdvancedMaterials,27,pp.4411–4417,2015.Ma,X.Qu,W.Zhu,Y.-S.Li,S.Yuan,H.Zhang,J.Liu,P.Wang,C.S.Lai,F.Zanella,G.-S.Feng,F.Sheikh,S.Chien*,S.C.Chen*,DeterministicallyPatternedBiomimeticHumaniPSC-derivedHepaticModelviaRapid3DBioprinting,ProceedingsoftheNationalAcademyofSciences(PNAS),Vol.113(no.8),pp.2206-2211,2016. HighlightedinNatureReviewsGastroenterologyHepatology,Feb24,2016.Zhu,X.Qu,J.Zhu,X.Ma,S.Patel,J.Liu,P.Wang,C.S.Lai,M.Gou,Y.Xu,K.Zhang,S.C.Chen*,Direct3Dbioprintingofprevascularizedtissueconstructswithcomplexmicroarchitecture,Biomaterials,Vol.124,pp.106-115,2017.Zhu+,K.R.Tringale+,S.A.Woller,S.You,S.Johnson,H.Shen,J.Schimelman,M.Whitney,J.Steinauer,W.Xu,T.L.Yaksh,Q.T.Nguyen*,S.C.Chen*,RapidContinuous3DPrintingofCustomizablePeripheralNerveGuidanceConduits,MaterialsToday,Vol.21(9),pp.951-959,2018.Ma,C.Yu,P.Wang,W.Xu,X.Wan,C.S.E.Lai,J.Liu,A.Koroleva-Maharajh,S.C.Chen*,Rapid3Dbioprintingofdecellularizedextracellularmatrixwithregionallyvariedmechanicalpropertiesandbiomimeticmicroarchitecture,Biomaterials,Vol.185,pp.310-321,2018,DOI:10.1016/j.biomaterials.2018.09.026Koffler+,W.Zhu+,X.Qu,O.Platoshyn,J.Dulin,J.Brock,L.Graham,P.Lu,J.Sakamoto,M.Marsala,S.C.Chen*,M.H.Tuszynski*,Biomimetic3D-PrintedScaffoldsforSpinalCordInjury,NatureMedicine,Vol.25,pp.263-269,2019. HighlightedinNatureReviewsNeuroscience,Jan.29,2019,reportedbyNIHDirectorsBlog on June6,2019.Tang,Q.Xie*,R.C.Gimple,Z.Zhong,T.Tam,J.Tian,R.L.Kidwell, Q.Wu,B.C.Prager,Z.Qiu,A.Yu,Z.Zhu,P.Mesci,H.Jing,J.Schimelman,P.Wang,D.Lee,M.H.Lorenzini, D. Dixit,L.Zhao,S.Bhargava,T.E.Miller,X.Wan,J.Tang,B.Sun,B.F.Cravatt,A.R.Muotri,S.C.Chen*,J.N.Rich*,Three-dimensionalbioprintingenablescreationoftissue-informedglioblastomamicroenvironmentsformodelingcomplexcellularinteractions,CellResearch,inpress,2020Wangpraseurt*,S.You,F.Azam,G.Jacucci,O.Gaidarenko,M.Hildebrand,M.Kühl,A.G.Smith,M.P.Davey,A.Smith,D.D.Deheyn,S.C.Chen*,S.Vignolini*,3DPrintedBionicCorals,NatureCommunications,Vol.11,1748(1-8),2020.。图十九、源于3D打印肝脏解毒装置(A)聚二乙炔纳米粒子包裹在PEGDA中的3D肝脏驱动解毒装置的荧光图像。
从最新的3D打印技术进展表明,小题它们有望满足这些要求。图九、源于3D打印的NOr-PGS将Nor-PGS3D打印为(A)立方体,源于(B)鼻子形和(C)耳朵形结构图十、聚氨酯的聚合机理(A)多元醇/多胺和扩链剂与过量二异氰酸酯之间的一级聚合。
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